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The Biosystems Design theme engineers microorganisms and plants to help overcome hurdles in health and sustainability.

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EZSpecificity combines extensive new enzyme-substrate docking data and a new machine learning algorithm to predict the best pairing for making a desired product, with up to 91.7% accuracy. Illinois professor Huimin Zhao led the study
Left image: First author of the study Xuenan Mi received an award in 2024 for her work on LassoESM. Right image: Professor Doug Mitchell, Professor Diwakar Shukla, and Susanna Barrett
Chemical and biomolecular engineering professor Huimin Zhao leads the new National Science Foundation iBioFoundry at the University of Illinois Urbana-Champaign. Photo by Michelle Hassel
Bioeconomy U: How Illinois is leading the bio-revolution
The CABBI research team and the iBioFAB biofoundry at the Carl R. Woese Institute for Genomic Biology (IGB). Front row, Graduate Student Seth Croslow and Research Scientist Jia Dong. Back row, from left: Co-PIs Mathew Hudson, Jonathan Sweedler, Huimin Zhao and Biofoundry Manager Stephan Lane. Credit: Julie Wurth/CABBI
From left to right: Shih-I (Harry) Tan, Zhixin Zhu, Hao Xu, Huimin Zhao.